Naagin in this season returns more powerful and this time she is battling an enemy that is bigger than ever before and avenge her countrymen. She is the Naagin of the new world - a world where a global crisis has emerged, where India is under a biological attack. A global pandemic has affected all countries and battered the world economy with seemingly no cure. The wise and spiritual leaders of the subcontinent foresee the imminent arrival of a catastrophe and they know there is only one who can counter it. They evoke Naagin and plead her to use her mystical powers to help, she agrees but on the condition that she will also seek her own personal vendetta from the people who wronged her.